Documented hypersensitivity to furosemide or sulfonamides.
Information about Furosemide.
There is no specific antidote to treat Lasix overdoseTherapy for correcting an overdose is symptomatic and is directed at correcting and restoring water-electrolyte balance.
Furosemide is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved CompoundsFind out more about compound libraries available from Tocris.
Pharmacodynamics Diuretic actionLoop diuretics inhibit sodium and chloride reabsorption in the proximal part of the ascending loop of Henlepromoting the excretion of sodiumwaterchlorideand potassiumAntihypertensive actionThis drug effect may be the result of renal and peripheral vasodilatation and a temporary increase in glomerular filtration rate and a decrease in peripheral vascular resistance.
Adverse effects of loop diuretics unrelated to the diuretic efficacy are rareand most adverse effects are due to abnormalities of fluid and electrolyte balanceHoweverloop diuretics can induce ototoxicity.
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torasemide often is substituted for furosemide once furosemide seems to be losing its effectiveness.